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Semin Cell Dev Biol. 2007 Oct;18(5):698-706. Epub 2007 Aug 25.

Moving chromatin within the interphase nucleus-controlled transitions?

Author information

1
Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign, B107 CLSL, 601 S. Goodwin Avenue, Urbana, IL 61801, USA.

Abstract

The past decade has seen an increasing appreciation for nuclear compartmentalization as an underlying determinant of interphase chromosome nuclear organization. To date, attention has focused primarily on describing differential localization of particular genes or chromosome regions as a function of differentiation, cell cycle position, and/or transcriptional activity. The question of how exactly interphase chromosome compartmentalization is established and in particular how interphase chromosomes might move during changes in nuclear compartmentalization has received less attention. Here we review what is known concerning chromatin mobility in relationship to physiologically regulated changes in nuclear interphase chromosome organization.

PMID:
17905613
PMCID:
PMC2117624
DOI:
10.1016/j.semcdb.2007.08.012
[Indexed for MEDLINE]
Free PMC Article

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