Abstract
Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / metabolism
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Basal Ganglia / drug effects*
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Basal Ganglia / physiopathology
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Choline / metabolism
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Creatine / metabolism
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Dominance, Cerebral / physiology
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Energy Metabolism / drug effects*
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Energy Metabolism / physiology
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Female
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Humans
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Image Processing, Computer-Assisted*
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Magnetic Resonance Spectroscopy*
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Male
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Middle Aged
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Neural Pathways / drug effects
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Neural Pathways / physiopathology
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Obsessive-Compulsive Disorder / drug therapy*
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Obsessive-Compulsive Disorder / physiopathology
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Selective Serotonin Reuptake Inhibitors / therapeutic use*
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Thalamus / drug effects*
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Thalamus / physiopathology
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Treatment Outcome
Substances
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Serotonin Uptake Inhibitors
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Aspartic Acid
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N-acetylaspartate
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Creatine
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Choline