Degradation of the neolignan, burchellin in the hemolymph of the bloodsucking insect Rhodnius prolixus

Marise M O Cabral; Eloi S Garcia; Otto R Gottlieb; Alphonse Kelecom

doi:10.1016/j.fitote.2007.07.004

Degradation of the neolignan, burchellin in the hemolymph of the bloodsucking insect Rhodnius prolixus

Fitoterapia. 2008 Jan;79(1):59-63. doi: 10.1016/j.fitote.2007.07.004. Epub 2007 Aug 9.

Authors

Marise M O Cabral¹, Eloi S Garcia, Otto R Gottlieb, Alphonse Kelecom

Affiliation

¹ Department of Biology, Universidade Severino Sombra, RJ, Brazil. mmaleck@ioc.fiocruz.br

PMID: 17904765
DOI: 10.1016/j.fitote.2007.07.004

Abstract

The neolignan, burchellin, a natural compound that reduces urine excretion in larvae of the bloodsucking bug, Rhodnius prolixus, a vector of Chagas' disease, is rapidly degraded in the hemolymph of the insect. The main product that accumulates in this tissue has been shown to be piperonyl alcohol. Other catabolites have been identified by GC-MS analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzofurans / blood*
Benzofurans / metabolism
Benzyl Alcohols / metabolism
Chagas Disease / prevention & control
Hemolymph / metabolism*
Lauraceae*
Pesticides / pharmacology*
Plant Extracts / metabolism*
Rhodnius / metabolism*
Structure-Activity Relationship

Substances

Benzofurans
Benzyl Alcohols
Pesticides
Plant Extracts
burchellin
piperonyl alcohol