Abstract
Methanolic extract of Butea monosperma flowers (MEBM) was studied for anti-inflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats. In carrageenin induced paw edema, MEBM at oral doses of 600 mg/kg and 800 mg/kg, dose-dependently inhibited the paw edema. In cotton pellet induced granuloma, MEBM at the same doses was found to significantly inhibit granuloma tissue formation, including significant reduction in levels of serum lysosomal enzymes (SGOT, SGPT and ALP) and lipid peroxides as compared to control.
MeSH terms
-
Alanine Transaminase / blood
-
Alkaline Phosphatase / blood
-
Animals
-
Anti-Inflammatory Agents / analysis*
-
Anti-Inflammatory Agents / therapeutic use
-
Aspartate Aminotransferases / blood
-
Butea / chemistry*
-
Carrageenan / adverse effects
-
Edema / chemically induced
-
Edema / drug therapy*
-
Female
-
Flowers / chemistry
-
Granuloma, Foreign-Body / drug therapy*
-
Lipid Peroxidation / drug effects
-
Male
-
Phytotherapy*
-
Plant Extracts / therapeutic use*
-
Rats
-
Rats, Wistar
Substances
-
Anti-Inflammatory Agents
-
Plant Extracts
-
Carrageenan
-
Aspartate Aminotransferases
-
Alanine Transaminase
-
Alkaline Phosphatase