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BMC Bioinformatics. 2007 Sep 27;8 Suppl 6:S7.

From biophysics to evolutionary genetics: statistical aspects of gene regulation.

Author information

1
Institut für Theoretische Physik, Universität zu Köln, Zülpicher Str, 77, 50937 Köln, Germany. lassig@thp.uni-koeln.de

Abstract

This is an introductory review on how genes interact to produce biological functions. Transcriptional interactions involve the binding of proteins to regulatory DNA. Specific binding sites can be identified by genomic analysis, and these undergo a stochastic evolution process governed by selection, mutations, and genetic drift. We focus on the links between the biophysical function and the evolution of regulatory elements. In particular, we infer fitness landscapes of binding sites from genomic data, leading to a quantitative evolutionary picture of regulation.

PMID:
17903288
PMCID:
PMC1995540
DOI:
10.1186/1471-2105-8-S6-S7
[Indexed for MEDLINE]
Free PMC Article

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