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Nat Methods. 2007 Oct;4(10):817-21.

Decoding protein modifications using top-down mass spectrometry.

Author information

1
Department of Chemistry, University of Illinois at Urbana-Champaign, 53 Roger Adams Laboratory, 600 South Matthews Avenue, Urbana, Illinois 61801, USA.

Abstract

Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present in vivo by measuring them intact, rather than measuring peptides produced from them by proteolysis. The top-down technology is beginning to capture the interest of biologists and mass spectrometrists alike, with a main goal of deciphering interaction networks operative in cellular pathways. Here we outline recent approaches and applications of top-down mass spectrometry as well as an outlook for its future.

PMID:
17901871
PMCID:
PMC2365886
DOI:
10.1038/nmeth1097
[Indexed for MEDLINE]
Free PMC Article
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