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Pediatr Infect Dis J. 2007 Oct;26(10):966-7.

Hypotonic and hyporesponsive episodes after diptheria-tetanus-acellular pertussis vaccination.

Author information

1
David Geffen School of Medicine, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA.

Abstract

Administration of the discontinued diphtheria-pertussis-tetanus vaccine was occasionally associated with a hypotonic-hyporesponsive episode in infants. The whole bacterial cell pertussis component was the likely culprit. For this reason, an acellular pertussis component was developed and incorporated into a new vaccine commonly called diptheria-tetanus-acellular pertussis (DTaP). Administration of DTaP vaccine has been followed by remarkably few hypotonic or hyporesponsive episodes. This report describes one of these unusual events.

PMID:
17901810
DOI:
10.1097/INF.0b013e318141ffc2
[Indexed for MEDLINE]

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