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Nat Prod Rep. 2007 Oct;24(5):1073-109. Epub 2007 May 10.

Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics.

Author information

1
KtedoGen, via Fantoli 16/15, 20132 Milan, Italy. stefano.donadio@ktedogen.com

Abstract

A total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of genes encoding modular polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). We report on the distribution of these systems in different bacterial taxa and, whenever known, the metabolites they synthesize. We also highlight, in the different bacterial lineages, the PKS and NRPS genes and, whenever known, the corresponding products.

PMID:
17898898
DOI:
10.1039/b514050c
[Indexed for MEDLINE]

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