Comparison of latency to seizure onset and of hyperventilation in two established rodent models of experimental febrile seizures [,,]. In the first model (shown in fuchsia), which uses a hair-dryer to emit a warmed stream of air, seizures commence within 2.9 ± 0.1 min after the initiation of the heating procedure. Increase of temperature is rapid, rising from 33.4 ± 0.16 °C to 40.74 ± 0.13 °C (the seizure-threshold temperature) in 2.9 min, with little change in respiratory rates: 161.8 ± 2.6 (n = 12) at baseline and 166.9 ± 4.9 during the minute preceding seizure onset [p = 0.37 versus baseline (values in the graph are shown as mean ± SEM; derived from [,]). In the second model, in which rats are placed in a heated chamber, seizures commence approximately 31 min after initiation of the heating procedure, when body temperature rises from 33.4 ± 0.9 to 41.8 ± 0.7 °C. Respiratory rate begins to increase significantly approximately 15 min into the procedure and the increased respiratory rate over approximately 15 min before the onset of the seizures promotes brain alkalosis (derived from []).