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Ophthalmic Epidemiol. 2007 Jul-Aug;14(4):184-7.

Overview of progress in the epidemiology of age-related macular degeneration.

Author information

1
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA. kleinr@epi.ophth.wisc.edu

Abstract

PURPOSE:

To provide an over-view of progress in the epidemiology of age-related macular degeneration.

METHODS:

Review of epidemiological and clinical trial findings regarding AMD since initial National Eye Institute sponsored epidemiology meeting in 1982.

RESULTS:

A growing number new epidemiological studies have provided data on the prevalence and long-term incidence of AMD. Despite a similar prevalence of early AMD in whites, blacks, and hispanics, whites have higher prevalence of late AMD. An age-period cohort effect has been shown in the Beaver Dam Eye Study suggesting that AMD incidence may be declining among younger birth cohorts. Genetic factors such as complement factor H have been shown to be strongly associated with AMD. Smoking is strongly related to risk of AMD. Randomized controlled clinical trials have shown the benefits of zinc-antioxidant supplementation in preventing visual loss in persons with signs of early AMD and anti-vascular endothelial growth factor agents in restoring vision in eyes with neovascular AMD.

CONCLUSIONS:

Despite remarkable progress in understanding AMD, many questions remain that can only be addressed by continuation of longitudinal population-based studies.

PMID:
17896295
DOI:
10.1080/09286580701344381
[Indexed for MEDLINE]

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