Format

Send to

Choose Destination
See comment in PubMed Commons below
J Mol Med (Berl). 2008 Feb;86(2):135-44. Epub 2007 Sep 22.

Pericytes: gatekeepers in tumour cell metastasis?

Author information

1
Vascular Biology Laboratory, London Research Institute-Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK. holger.gerhardt@cancer.org.uk

Abstract

Tumour cells use two major routes to spread during metastasis, e.g. lymph vessels and blood vessels within or surrounding the primary tumour. The growth rate of the primary tumour often correlates with the quantity of new blood vessels that form within the tumour. However, qualitative abnormalities of the tumour vasculature profoundly affect the perfusion of the primary tumour and the escape of tumour cells into the circulation. In this paper, we review recent evidence for a novel role of the supporting mural cells in limiting blood-borne metastasis.

PMID:
17891366
DOI:
10.1007/s00109-007-0258-2
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center