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Cell Cycle. 2007 Sep 15;6(18):2246-51. Epub 2007 Jun 29.

The ribosome filter redux.

Author information

1
Department of Neurobiology, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA. vmauro@scripps.edu

Abstract

The ribosome filter hypothesis postulates that ribosomes are not simply translation machines but also function as regulatory elements that differentially affect or filter the translation of particular mRNAs. On the basis of new information, we take the opportunity here to review the ribosome filter hypothesis, suggest specific mechanisms of action, and discuss recent examples from the literature that support it.

PMID:
17890902
PMCID:
PMC2930609
DOI:
10.4161/cc.6.18.4739
[Indexed for MEDLINE]
Free PMC Article

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