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Appl Environ Microbiol. 2007 Nov;73(22):7465-70. Epub 2007 Sep 21.

Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula.

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1
Division of Microbiology, Armed Forces Institute of Pathology, Washington, DC, USA.

Abstract

Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

PMID:
17890329
PMCID:
PMC2168206
DOI:
10.1128/AEM.00646-07
[Indexed for MEDLINE]
Free PMC Article
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