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Cell. 2007 Sep 21;130(6):986-8.

Non-oncogene addiction and the stress phenotype of cancer cells.

Author information

1
Howard Hughes Medical Institute and Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.

PMID:
17889643
DOI:
10.1016/j.cell.2007.09.007
[Indexed for MEDLINE]
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