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Diagn Microbiol Infect Dis. 2008 Jan;60(1):117-20. Epub 2007 Sep 21.

False-positive Aspergillus antigen testing due to application of piperacillin/tazobactam--is it still an issue?

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Hematology and Oncology, Campus Benjamin Franklin, D-12200 Berlin, Germany.


We evaluated the impact of piperacillin/tazobactam (PT) therapy on galactomannan enzyme immunoassay (GEI) testing (Platelia; Bio-Rad, Marnes La Coquette, France). Galactomannan contents of PT batches were highly variable. We found that false-positive GEI results can be avoided by performance of blood sampling before PT administration and by using separate sites for blood sampling and for administration of antibiotics.

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