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Prog Neurobiol. 2007 Oct;83(3):131-9. Epub 2007 Aug 19.

The role of intracellular amyloid beta in Alzheimer's disease.

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1
Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.

Abstract

Extracellular amyloid beta (Abeta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, Abeta also accumulates inside the AD neurons. This intracellular Abeta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of Abeta in AD. Therapeutics targeting intracellular Abeta could be effective treatment for AD.

PMID:
17889422
DOI:
10.1016/j.pneurobio.2007.08.002
[Indexed for MEDLINE]
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