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Bioorg Chem. 2007 Dec;35(6):465-9. Epub 2007 Sep 21.

OMP decarboxylase--An enigma persists.

Author information

1
Division of Infectious Disease, Wadsworth Center--NYS-DOH, Albany, NY 12202, USA. callahan@wadsworth.org

Abstract

In 1995, Radzicka and Wolfenden reported that the rate enhancement produced by orotidine 5'-phosphate decarboxylase (ODCase) approaches 10(17), making this enzyme the most effective pure protein catalyst known in Nature [A. Radzicka, R. Wolfenden, Science 267 (1995) 90-93]. Over the last 12 years, there have been many hypotheses put forward to explain that impressive effect. In this perspective, we provide a summary of the reaction pathways under consideration for ODCase, highlight the supporting and refuting data, and suggest experiments designed to further test each of the candidate pathways.

PMID:
17889251
DOI:
10.1016/j.bioorg.2007.07.004
[Indexed for MEDLINE]

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