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Microb Pathog. 2008 Feb;44(2):159-63. Epub 2007 Aug 11.

A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes.

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  • 1Department of Pediatrics and Microbiology, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA.

Abstract

Attenuated recombinant Listeria monocytogenes (Lm) strains are a promising class of vaccine vectors that trigger protective antigen-specific CD8 T cells. Listeriolysin O (LLO) is an important Lm virulence determinant allowing the bacterium to escape from the endocytic vacuole into the cell cytoplasm in phagocytic cells. However in non-phagocytic cells, Lm phospholipase C can also mediate cytoplasmic entry. The ability of LLO-deficient Lm to confer long-term protection to infection is uncertain. Herein, we demonstrate that LLO-deficient Lm mutants can prime protective immunity to subsequent Lm infection and that Lm phospholipase C is required for protective immunity conferred by LLO-deficient Lm.

PMID:
17888620
PMCID:
PMC2276143
DOI:
10.1016/j.micpath.2007.08.002
[PubMed - indexed for MEDLINE]
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