Format

Send to

Choose Destination
Fertil Steril. 2008 Aug;90(2):391-4. Epub 2007 Sep 20.

The effect of interleukin-6 on ciliary beat frequency in the human fallopian tube.

Author information

1
Academic Department of Obstetrics and Gynaecology, Bart's and The London and Newham University Hospitals and Queen Mary's School of Medicine and Dentistry, London, United Kingdom.

Abstract

OBJECTIVE:

To investigate the effect of interleukin-6 (IL-6) on ciliary activity within the human fallopian tube in vitro.

DESIGN:

An experimental laboratory-based study.

SETTING:

University teaching hospital.

PATIENT(S):

Fallopian tube specimens were obtained from eight women undergoing hysterectomy for fibroid uterus.

MAIN OUTCOME MEASURE(S):

Ciliary beat frequency (CBF) in the human fallopian tube.

INTERVENTION(S):

After baseline CBF measurements, increasing concentrations of IL-6 (10 pg/mL, 100 pg/mL, and 1000 pg/mL) were applied to fallopian tube mucosa explants and CBF measurements repeated. An anti-IL-6 monoclonal antibody was added and CBF measured once more. Negative and antibody-only control samples were used.

RESULT(S):

The CBF remained unchanged with the addition of IL-6 at concentrations of 10 pg/mL and 100 pg/mL but IL-6 at 1000 pg/mL significantly decreased CBF, an effect abolished by the addition of the specific antibody.

CONCLUSION(S):

These data suggest that IL-6 has an inhibitory effect on ciliary activity, suggesting a possible role for this cytokine in the subfertility process. This finding may be important in conditions where there are increased IL-6 levels in the peritoneal fluid, such as endometriosis and pelvic inflammatory disease.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center