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J Cell Physiol. 2007 Dec;213(3):649-53.

The integrin-growth factor receptor duet.

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1
Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Abstract

Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.

PMID:
17886260
DOI:
10.1002/jcp.21278
[Indexed for MEDLINE]
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