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Neuroreport. 2007 Oct 8;18(15):1547-51.

Intracellular dynamics of calcyon, a neuron-specific vesicular protein.

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Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden.


Calcyon is a brain-specific protein, implicated in clathrin-mediated endocytosis. In this descriptive study we show that calcyon is exclusively expressed in neurons, and localized in moving vesicles. The movement of calcyon-containing vesicles was dependent on temperature and on intact microtubules, in addition these vesicles were colocalized with a marker for endocytosed plasma membrane proteins, suggesting that calcyon vesicles follow the endocytic recycling pathway. We also show using evanescent wave microscopy that there is a pool of ready releasable calcyon vesiclesaccumulated beneath the plasma membrane. We conclude that the mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity.

[Indexed for MEDLINE]

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