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Int J Gynecol Pathol. 2007 Oct;26(4):494-6.

Aggressive angiomyxoma of the vulva with a sole t(5;8)(p15;q22) chromosome change.

Author information

1
Department of Reproductive Pathophysiology and Obstetrics-Gynecology, Field of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. tsujita@m3.kufm.kagoshima-u.ac.jp

Abstract

Aggressive angiomyxoma of the vulva is uncommon and the pathogenesis remains unclear. Recently, a few cytogenetic studies demonstrated chromosomal abnormalities in aggressive angiomyxoma of the vulva. A 45-year-old Japanese woman complaining of right-side vulva tumor measuring 3 cm in diameter was referred to our hospital. The mass was located at the right side of the rectovaginal septum and was closely adherent to the rectal serosa and the levator muscle ani. The tumor was completely resected. A pathological examination demonstrated aggressive angiomyxoma of the vulva. Chromosomal analysis of the tumor demonstrated a sole t(5;8)(p15;q22) translocation. This is the first case of an aggressive angiomyxoma of the vulva with a sole t(5;8)(p15;q22) translocation.

PMID:
17885504
DOI:
10.1097/pgp.0b013e31802cbc05
[Indexed for MEDLINE]

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