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Curr Opin Chem Biol. 2007 Oct;11(5):480-4. Epub 2007 Sep 19.

Natural products as a screening resource.

Author information

1
Strathclyde Institute for Drug Research, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK. a.l.harvey@strath.ac.uk

Abstract

Natural products have been the most productive source of leads for new drugs, but they are currently out of fashion with the pharmaceutical industry. New approaches to sourcing novel compounds from untapped areas of biodiversity coupled with the technical advances in analytical techniques (such as microcoil NMR and linked LC-MS-NMR) have removed many of the difficulties in using natural products in screening campaigns. As the 'chemical space' occupied by natural products is both more varied and more drug-like than that of combinatorial chemical collections, synthetic and biosynthetic methods are being developed to produce screening libraries of natural product-like compounds. A renaissance of drug discovery inspired by natural products can be predicted.

PMID:
17884696
DOI:
10.1016/j.cbpa.2007.08.012
[Indexed for MEDLINE]
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