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Bioorg Med Chem Lett. 2007 Nov 15;17(22):6183-7. Epub 2007 Sep 8.

New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists.

Author information

1
Department of Medicinal Chemistry, AstraZeneca R&D Montreal, St-Laurent, Quebec, Canada. daniel.page@astrazeneca.com

Abstract

The preparation and evaluation of a novel class of CB2 agonists based on a 1,2,3,4-tetrahydropyrrolo[3,4-b]indole moiety are reported. They showed binding affinities up to 4.2 nM toward CB2 with sub-nanomolar EC(50) values. They also showed moderate to good (>350-fold) selectivity over the CB1 receptor.

PMID:
17884494
DOI:
10.1016/j.bmcl.2007.09.019
[Indexed for MEDLINE]

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