Abstract
Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented.
MeSH terms
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Animals
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Cell Line
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Humans
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Insecticides / chemical synthesis
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Insecticides / chemistry
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Insecticides / pharmacology*
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Lepidoptera / cytology
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Lepidoptera / drug effects*
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Mice
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Molecular Structure
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Rats
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Ryanodine Receptor Calcium Release Channel / drug effects*
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Structure-Activity Relationship
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Toxicity Tests, Acute
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Up-Regulation / drug effects
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ortho-Aminobenzoates / chemical synthesis
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ortho-Aminobenzoates / chemistry
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ortho-Aminobenzoates / pharmacology*
Substances
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Insecticides
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Ryanodine Receptor Calcium Release Channel
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ortho-Aminobenzoates
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chlorantranilipole