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Gene. 2007 Nov 15;403(1-2):39-52. Epub 2007 Aug 23.

Polyphasic evidence delineating the root of life and roots of biological domains.

Author information

1
Department of Biochemistry and Applied Genomics Center, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China. bcjtw@ust.hk

Abstract

Twenty different lines of polyphasic evidence obtained from tRNA and protein sequences, anticodon usages, gene contents, metabolism and geochemistry have made possible the identification of a Last Universal Common Ancestor (LUCA) phylogenetically located proximal to the hyperthermophilic methanogenic archaeon Methanopyrus. Combined with analysis of high-similarity cross-domain tRNA pairs, the evidence also suggests a Thermotoga-proximal Last Bacterial Common Ancestor (LBACA) that originated from Crenarchaeota close to Aeropyrum, and a Plasmodium-proximal Last Eukaryotic Common Ancestor (LECA) derived from Ferroplasma through endosymbiosis.

PMID:
17884304
DOI:
10.1016/j.gene.2007.07.032
[Indexed for MEDLINE]

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