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Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):336-9. Epub 2007 Aug 29.

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline.

Author information

  • 1Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan.

Abstract

BACKGROUND:

The N-methyl-d-aspartate (NMDA) receptor antagonist phencyclidine (PCP)-induced cognitive deficits have been used as an animal model for schizophrenia. This study was undertaken to determine whether the antibiotic drug minocycline could improve PCP-induced cognitive deficits in mice.

METHODS:

Saline (10 ml/kg/day, s.c., once daily on day 1-5, 8-12) or PCP (10 mg/kg/day, s.c., once daily on day 1-5, 8-12) were administered to mice for 10 days. Subsequently, vehicle (10 ml/kg/day, i.p.) or minocycline (4.0 or 40 mg/kg/day, i.p.) was injected for 14 consecutive days. One day after the final injection, a novel object recognition test was performed.

RESULTS:

PCP-induced cognitive deficits in mice were significantly improved by subsequent subchronic (14 days) administration of minocycline (40 mg/kg), but not minocycline (4.0 mg/kg).

CONCLUSIONS:

This study suggests that minocycline could be a potential therapeutic drug for cognitive deficits in schizophrenic patients.

PMID:
17884273
DOI:
10.1016/j.pnpbp.2007.08.031
[PubMed - indexed for MEDLINE]
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