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J Autism Dev Disord. 2008 May;38(5):827-39.

The modified checklist for autism in toddlers: a follow-up study investigating the early detection of autism spectrum disorders.

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  • 1Department of Psychology, University of Connecticut, 406 Babbidge Rd., Storrs, CT 06269-1020, USA. jamie_kleinman@yahoo.com

Abstract

Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16-30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Rescreening was performed on 1,416 children aged 42-54 months. Time 1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the followup telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD.

PMID:
17882539
PMCID:
PMC3612529
DOI:
10.1007/s10803-007-0450-9
[PubMed - indexed for MEDLINE]
Free PMC Article
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