Cross-validation was performed between an in-house dose-to-water (D(water)) calculation method used at Virginia Commonwealth University and the VMC++ D(water) calculation during particle transport. The effect of Monte Carlo statistical precision was observed. The results of the two calculations on homogeneous phantoms with densities varying from 0.3 g cm(-3) to 2.95 g cm(-3) were compared. Depth and field size dependence were tested. D(water) calculations were compared in a bone-lung-bone phantom to observe how the calculations differed in steep density gradients. The methods were compared for five prostate and five head-and-neck (H/N) patient cases as well. In all phantom tests, the differences between the two D(water) calculations were less than 1%. The largest differences in patient cases was a prostate case in which 1% of the voxels with doses greater than 50% of the maximum dose had a systematic difference corresponding to 1.16% of the maximum dose. All differences were clinically insignificant.