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Curr Infect Dis Rep. 2007 Sep;9(5):382-6.

Long-term outcomes from sepsis.

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Department of Critical Care Medicine, University of Pittsburgh, 642A Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.


Long-term mortality following severe sepsis is high, and fewer than half of patients who experience severe sepsis are alive at 1 year. Mechanisms underlying increased long-term mortality remain poorly understood. Animal and human studies suggest that abnormalities of the innate immune system may contribute to increased long-term mortality. This review article examines the epidemiology and potential mechanisms underlying long-term outcomes from sepsis and challenges to conducting long-term outcome studies in the critically ill.


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