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Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15531-6. Epub 2007 Sep 18.

Resting-state networks in the infant brain.

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Magnetic Resonance Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden.


In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map patterns of resting-state activity in infants during sleep. We found five unique resting-states networks in the infant brain that encompassed the primary visual cortex, bilateral sensorimotor areas, bilateral auditory cortex, a network including the precuneus area, lateral parietal cortex, and the cerebellum as well as an anterior network that incorporated the medial and dorsolateral prefrontal cortex. These results suggest that resting-state networks driven by spontaneous signal fluctuations are present already in the infant brain. The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed.

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