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Proc Biol Sci. 2007 Dec 7;274(1628):2925-33.

Susceptible-infected-recovered epidemics in dynamic contact networks.

Author information

1
Department of Integrative Biology, University of Texas at Austin, 1 University Station, C0930, Austin, TX 78712, USA. erik.volz@mail.utexas.edu

Erratum in

  • Proc Biol Sci. 2008 Dec 22;275(1653):2898.

Abstract

Contact patterns in populations fundamentally influence the spread of infectious diseases. Current mathematical methods for epidemiological forecasting on networks largely assume that contacts between individuals are fixed, at least for the duration of an outbreak. In reality, contact patterns may be quite fluid, with individuals frequently making and breaking social or sexual relationships. Here, we develop a mathematical approach to predicting disease transmission on dynamic networks in which each individual has a characteristic behaviour (typical contact number), but the identities of their contacts change in time. We show that dynamic contact patterns shape epidemiological dynamics in ways that cannot be adequately captured in static network models or mass-action models. Our new model interpolates smoothly between static network models and mass-action models using a mixing parameter, thereby providing a bridge between disparate classes of epidemiological models. Using epidemiological and sexual contact data from an Atlanta high school, we demonstrate the application of this method for forecasting and controlling sexually transmitted disease outbreaks.

PMID:
17878137
PMCID:
PMC2291166
DOI:
10.1098/rspb.2007.1159
[Indexed for MEDLINE]
Free PMC Article

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