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Antimicrob Agents Chemother. 2007 Dec;51(12):4518-20. Epub 2007 Sep 17.

RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection.

Author information

1
Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy. anconacmi@interfree.it

Abstract

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

PMID:
17875996
PMCID:
PMC2167994
DOI:
10.1128/AAC.00808-07
[Indexed for MEDLINE]
Free PMC Article

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