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Urologe A. 2007 Oct;46(10):1364, 1366-8, 1370.

[The Prostate Cancer Prevention Trial (PCPT). Relevance for clinical practice].

[Article in German]

Author information

1
Urologie, EuromedClinic, Europa-Allee 1, 90763 Fürth. bsd@euromed.de

Abstract

The Prostate Cancer Prevention Trial (PCPT) has been the first interventional trial directly aimed at the prevention of prostate cancer. A total of 18,882 men over 55 years with a PSA serum level less than 3.0 ng/ml were randomized to receive either the 5-alpha-reductase inhibitor finasteride 5 mg/day or placebo for 7 years. Despite a 25% reduction of prostate cancers in the treatment arm the results were discussed controversially. This criticism was mainly due to the observation of significantly more high-grade cancers in the finasteride group. Meanwhile, results of extensive follow-up analyses have been published suggesting that this finding is most likely due to optimized tumor detection in smaller glands. Further work-up demonstrated that PSA diagnosis and the histopathological examination were not compromised by finasteride. Furthermore, in addition to a decrease of prostate cancer the amount of prostatic intraepithelial dysplasia (PIN) was also reduced under finasteride. Future research must now aim at defining high-risk groups specifically profiting from chemoprevention with a 5-alpha-reductase inhibitor.

PMID:
17874228
DOI:
10.1007/s00120-007-1553-9
[Indexed for MEDLINE]
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