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Histochem Cell Biol. 2007 Nov;128(5):457-71. Epub 2007 Sep 15.

A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct populations of enteroendocrine cells.

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University of Hohenheim, Institute of Physiology, Garbenstrasse 30, 70599, Stuttgart, Germany.


In the gastrointestinal (GI) tract, a variety of digestive processes are continually adapted to the changing composition of ingested foods, which requires a precise chemosensory monitoring of luminal contents. Gustducin-expressing brush cells scattered throughout the GI mucosa are considered candidate sensory cells for accomplishing this task. In this study, we have investigated a large cluster of gustducin-positive cells which is located exactly at the boundary between the fundic and the oxyntic mucosa of the mouse stomach, at the so-called "limiting ridge". In close association with the candidate chemosensory cluster, we found two populations of enteroendocrine cells: one population containing the satiety regulating hormone ghrelin, the other population comprising serotonin-secreting enterochromaffin cells. The particular arrangement of gustducin-expressing cells and enteroendocrine cells at the limiting ridge suggests a direct interplay between these cell types with immediate implications, not only for digestive processes in the stomach, but also for parameters controlling the satiety status.

[Indexed for MEDLINE]

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