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Nat Genet. 2007 Oct;39(10):1208-16. Epub 2007 Sep 16.

Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes.

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1
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA. hgoring@sfbrgenetics.org

Abstract

Quantitative differences in gene expression are thought to contribute to phenotypic differences between individuals. We generated genome-wide transcriptional profiles of lymphocyte samples from 1,240 participants in the San Antonio Family Heart Study. The expression levels of 85% of the 19,648 detected autosomal transcripts were significantly heritable. Linkage analysis uncovered >1,000 cis-regulated transcripts at a false discovery rate of 5% and showed that the expression quantitative trait loci with the most significant linkage evidence are often located at the structural locus of a given transcript. To highlight the usefulness of this much-enlarged map of cis-regulated transcripts for the discovery of genes that influence complex traits in humans, as an example we selected high-density lipoprotein cholesterol concentration as a phenotype of clinical importance, and identified the cis-regulated vanin 1 (VNN1) gene as harboring sequence variants that influence high-density lipoprotein cholesterol concentrations.

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PMID:
17873875
DOI:
10.1038/ng2119
[Indexed for MEDLINE]
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