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Gut. 2007 Oct;56(10):1333-6.

The IL23 axis plays a key role in the pathogenesis of IBD.

Author information

1
Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK. dermotmcgovern@doctors.net.uk

Abstract

Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.

PMID:
17872562
PMCID:
PMC2000291
DOI:
10.1136/gut.2006.115402
[Indexed for MEDLINE]
Free PMC Article
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