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J Am Acad Dermatol. 2007 Oct;57(4):722-4.

Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug.

Author information

1
University of Toledo School of Medicine, Sylvania, Ohio, USA.

Abstract

The Propionibacterium acnes biofilm has previously been shown to exist via genomic studies and to make a biological glue which allows for adherence to follicular walls. This gylcocalyx polymer secreted by P acnes also finds its way into sebum composition where it causes the adhesiveness of keratinocytes leading to comedones. An appreciation of P acnes biofilms and secretions has implications in immunogenicity of the organism, clinical course of acne, and therapy for comedonal and inflammatory acne.

PMID:
17870436
DOI:
10.1016/j.jaad.2007.05.013
[Indexed for MEDLINE]

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