Format

Send to

Choose Destination
See comment in PubMed Commons below
J Crit Care. 2007 Sep;22(3):229-35. Epub 2007 Jan 31.

Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy.

Author information

1
Department of Neurosurgery, Hangzhou Second Hospital, School of Medicine, Hangzhou Normal College, Hangzhou 310012, China. shihai954@163.com

Abstract

PURPOSE:

We investigated the effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy (TBI).

METHODS:

Eighty patients with severe TBI after unilateral craniotomy were randomized into a therapeutic hypothermia group with the brain temperature maintained at 33 degrees C to 35 degrees C for 4 days, and a normothermia control group in the intensive care unit. Vital signs, intracranial pressure, serum superoxide dismutase level, Glasgow Outcome Scale scores, and complications were prospectively analyzed.

RESULTS:

The mean intracranial pressure values of the therapeutic hypothermia group at 24, 48, and 72 hours after injury were much lower than those of the control group (23.49 +/- 2.38, 24.68 +/- 1.71, and 22.51 +/- 2.44 vs 25.87 +/- 2.18, 25.90 +/- 1.86, and 24.57 +/- 3.95 mm Hg; P = .000, .000, and .003, respectively). The mean serum superoxide dismutase levels of the therapeutic hypothermia group at days 3 and 7 were much higher than those of the control group at the same time point (533.0 +/- 103.4 and 600.5 +/- 82.9 vs 458.7 +/- 68.1 and 497.0 +/- 57.3 mug/L, respectively; P = .000). The percentage of favorable neurologic outcome 1 year after injury was 70.0% and 47.5%, respectively (P = .041). Complications, including pulmonary infections (57.5% in the therapeutic hypothermia group vs 32.5% in the control group; P = .025) were managed without severe sequelae.

CONCLUSIONS:

Therapeutic mild hypothermia provides a promising way in the intensive care unit for patients with severe TBI after craniotomy.

PMID:
17869973
DOI:
10.1016/j.jcrc.2006.06.011
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center