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Bioorg Med Chem Lett. 2007 Nov 1;17(21):5858-62. Epub 2007 Aug 15.

A novel class of potent NF-kappaB signaling inhibitors.

Author information

1
4SC AG, Am Klopferspitz 19a, 82152 Martinsried, Germany. leban@4sc.com

Abstract

A novel class of NF-kappaB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-kappaB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chemistry to yield nano-molar signaling inhibitors.

PMID:
17869512
DOI:
10.1016/j.bmcl.2007.08.022
[Indexed for MEDLINE]

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