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Immunity. 2007 Sep;27(3):493-504.

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells.

Author information

1
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, GA 30912, USA. rpacholczyk@mcg.edu

Abstract

The majority of regulatory Foxp3+CD4+ T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4+ T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery.

PMID:
17869133
PMCID:
PMC2276657
DOI:
10.1016/j.immuni.2007.07.019
[Indexed for MEDLINE]
Free PMC Article

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