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Genome Biol. 2007;8(9):R192.

InSite: a computational method for identifying protein-protein interaction binding sites on a proteome-wide scale.

Author information

  • 1Computer Science Department, Stanford University, Serra Mall, Stanford, CA 94305, USA. haidong@cs.stanford.edu

Abstract

We propose InSite, a computational method that integrates high-throughput protein and sequence data to infer the specific binding regions of interacting protein pairs. We compared our predictions with binding sites in Protein Data Bank and found significantly more binding events occur at sites we predicted. Several regions containing disease-causing mutations or cancer polymorphisms in human are predicted to be binding for protein pairs related to the disease, which suggests novel mechanistic hypotheses for several diseases.

PMID:
17868464
PMCID:
PMC2375030
DOI:
10.1186/gb-2007-8-9-r192
[PubMed - indexed for MEDLINE]
Free PMC Article
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