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Acta Odontol Scand. 2007 Oct;65(5):284-91.

Effect of supplementary amine fluoride gel in caries-active adolescents. A clinical QLF study.

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Department of Cariology and Endodontology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden.



To investigate whether supplementary daily use of amine fluoride toothpaste with weekly brushing with amine fluoride gel enhances the remineralization of white spot lesions on smooth surfaces and also to investigate the possible effect of this treatment on salivary bacterial counts and oral hygiene.


The participants comprised 135 caries-active adolescents living in suburban Stockholm. They were given an amine fluoride dentifrice (1250 ppm F) to be used twice a day, and either a test gel (4000 ppm F) or a placebo gel for brushing for 2 min once a week. During the 12-month study period, the subjects were recalled every 3rd month (baseline, 3, 6, 9, and 12 months). At each visit, DF(average change in fluorescence, in%) and lesion area (in mm2) were measured using quantitative light-induced fluorescence(QLF), followed by dietary counseling, oral hygiene instruction, and professional tooth-cleaning. At baseline, 6, and 12 months, saliva was sampled for Streptococcus mutans and lactobacillus counts, and gingival bleeding index was registered.


QLF indicated no enhancement of remineralization of white spot lesions by additional weekly brushing with amine fluoride gel. No inter-group differences emerged with regard to salivary bacterial counts. However, the oral hygiene of both groups improved, with a strong significance over time.


Adjunctive weekly brushing of amine fluoride gel achieved no significant enhancement of remineralization of white spot lesions monitored with the QLF method.

[Indexed for MEDLINE]

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