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Curr Opin Chem Biol. 2007 Oct;11(5):561-8. Epub 2007 Sep 11.

LSD1 and the chemistry of histone demethylation.

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1
Department of Pharmacology and Molecular Sciences, The Johns Hopkins School of Medicine, Baltimore, MD 21205, United States.

Abstract

The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.

PMID:
17851108
PMCID:
PMC2112775
DOI:
10.1016/j.cbpa.2007.07.014
[Indexed for MEDLINE]
Free PMC Article
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