Predictors of the evolution towards schizophrenia or mood disorder in patients with schizophreniform disorder

Carlo Marchesi; Matteo Paini; Luca Ruju; Luca Rosi; Giuliano Turrini; Carlo Maggini

doi:10.1016/j.schres.2007.08.014

Predictors of the evolution towards schizophrenia or mood disorder in patients with schizophreniform disorder

Schizophr Res. 2007 Dec;97(1-3):1-5. doi: 10.1016/j.schres.2007.08.014. Epub 2007 Sep 12.

Authors

Carlo Marchesi¹, Matteo Paini, Luca Ruju, Luca Rosi, Giuliano Turrini, Carlo Maggini

Affiliation

¹ Psychiatric Section, Department of Neuroscience, University of Parma, Parma, Italy. carlo.marchesi@unipr.it

PMID: 17851043
DOI: 10.1016/j.schres.2007.08.014

Abstract

In this study, 56 patients affected by schizophreniform disorder (SFD), as their first lifetime mental disorder, were re-evaluated 7.9+/-4.7 yrs (2-17 yrs) after their first hospitalization. At follow-up, schizophrenia (SC) was diagnosed in 25 patients (46%), a mood disorder (MD) in 19 (35%), a non-SC psychotic disorder in 10 (18%) and no disorder in 2 (4%). The evolution towards SC was predicted by the presence of blunted affect (OR: 1.88) and by poor pre-morbid functioning (OR: 1.10) at the index hospitalization. Our data suggest that SFD may represent the first psychotic presentation of different disorders and the evolution towards SC or a MD seems to be influenced by the pre-morbid level of functioning and by the presence of blunted affect.

MeSH terms

Adolescent
Adult
Affective Symptoms / diagnosis
Affective Symptoms / psychology
Bipolar Disorder / diagnosis*
Bipolar Disorder / psychology
Brief Psychiatric Rating Scale
Comorbidity
Depressive Disorder, Major / diagnosis*
Depressive Disorder, Major / psychology
Female
Humans
Male
Middle Aged
Psychotic Disorders / diagnosis*
Psychotic Disorders / psychology
Risk Factors
Schizophrenia / diagnosis*
Schizophrenic Psychology*
Social Adjustment