The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association

Neurobiol Aging. 2009 Apr;30(4):666-8. doi: 10.1016/j.neurobiolaging.2007.07.018. Epub 2007 Sep 11.

Abstract

Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.

MeSH terms

  • Aged
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Amyloid beta-Peptides / genetics
  • Brain / metabolism*
  • Brain / physiopathology
  • Cohort Studies
  • DNA Mutational Analysis
  • Female
  • Gene Frequency / genetics
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genetic Variation / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • PPAR alpha / analysis
  • PPAR alpha / genetics*
  • PPAR alpha / metabolism
  • Polymorphism, Single Nucleotide / genetics*
  • Predictive Value of Tests
  • Reproducibility of Results
  • tau Proteins / genetics

Substances

  • Amyloid beta-Peptides
  • Genetic Markers
  • PPAR alpha
  • tau Proteins