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J Antimicrob Chemother. 2007 Nov;60(5):1155-8. Epub 2007 Sep 10.

Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro.

Author information

  • 1Medical Research Council (MRC) Unit for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, and Tshwane Academic Division of the National Health Laboratory Service, South Africa. ronald.anderson@up.ac.za

Abstract

OBJECTIVES:

To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae.

METHODS:

Pneumolysin was assayed using a functional procedure based on the influx of Ca(2+) into human neutrophils.

RESULTS:

Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus.

CONCLUSIONS:

Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae.

PMID:
17848373
DOI:
10.1093/jac/dkm338
[PubMed - indexed for MEDLINE]
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