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Am J Hum Genet. 2007 Oct;81(4):829-34. Epub 2007 Aug 20.

Allele-specific targeting of microRNAs to HLA-G and risk of asthma.

Author information

1
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. tzheng@bsd.uchicago.edu

Erratum in

  • Am J Hum Genet. 2008 Jan;82(1):251.

Abstract

HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.

PMID:
17847008
PMCID:
PMC2227932
DOI:
10.1086/521200
[Indexed for MEDLINE]
Free PMC Article

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