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Nat Rev Genet. 2007 Oct;8(10):776-90. Epub 2007 Sep 11.

Ribozymes, riboswitches and beyond: regulation of gene expression without proteins.

Author information

1
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. serganoa@mskcc.org

Abstract

Although various functions of RNA are carried out in conjunction with proteins, some catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little or no assistance from proteins. Furthermore, the discovery of metabolite-sensing riboswitches and other types of RNA sensors has revealed RNA-based mechanisms that cells use to regulate gene expression in response to internal and external changes. Structural studies have shown how these RNAs can carry out a range of functions. In addition, the contribution of ribozymes and riboswitches to gene expression is being revealed as far more widespread than was previously appreciated. These findings have implications for understanding how cellular functions might have evolved from RNA-based origins.

PMID:
17846637
PMCID:
PMC4689321
DOI:
10.1038/nrg2172
[Indexed for MEDLINE]
Free PMC Article

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