Format

Send to

Choose Destination
Trends Cell Biol. 2007 Sep;17(9):438-47. Epub 2007 Sep 12.

The Gli code: an information nexus regulating cell fate, stemness and cancer.

Author information

1
Department of Genetic Medicine and Development, 8242 CMU, University of Geneva Medical School, 1 rue Michel Servet, CH-1211 Geneva, Switzerland. Ariel.RuizAltaba@medecine.unige.ch

Abstract

The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.

PMID:
17845852
PMCID:
PMC2601665
DOI:
10.1016/j.tcb.2007.06.007
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center